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Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.Based on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylationmetabolism are the possible up-stream factors that inactivate PP2A in AD neurons.Further studies are required to disclose the role of PP2A in Alzheimer’s disease.

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, protein phosphatase2A (PP2A) activity, and on tau phosphorylation.of Src protein, and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2AHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.Multiple factors may be involved in the cellular regulation of PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Strategic Study of CAE 2002, Volume 4, Issue 10,   Pages 40-47

Abstract:

Shigella flexneri serotype 2a are the most prevalent species and serotype that cause .bacillary dysenteryThis paper presents the complete genome sequence of a Shigella flexneri 2a strain which isolated fromthe primary analysis of “ Shigella-genomic islands (SIs)，” that means Shigella flexneri 2athem, the authors identified 7 putative Sis with typical structure of pathogenicity islands (PAI) and 2lipopolysaccharide (LPS) have implications in virulence, in addition to the previously identified PAIs, SHE and SHI-2.

Keywords： Shigella flexneri 2a 301 strain     genome sequence     genomic island     pathogenicity island    

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Measurement of bone alkaline phosphatase and relative study with osteosarcoma

YANG Zhiping, LI Jianmin, LI Xin, HUO Yanqing, SUN Guangzhi

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 54-57 doi: 10.1007/s11684-007-0011-9

Abstract: The objective of this paper is to explore the value of bone alkaline phosphatase (BALP) for diagnosingAlkaline phosphatase (ALP) in blood serum was checked with auto biochemistry equipment.
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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: The mRNA and protein expression of phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regenerating

Keywords： transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: phosphorylation on Tyr-410 in arterial smooth muscle, creating the binding site for the Src homology (SH) 2/Abelson tyrosine kinase (Abl), c-Src, focal adhesion kinase (FAK), proline-rich tyrosine kinase 2 (PYK2), protein tyrosine phosphatase-proline, glutamate, serine and threonine sequence protein (PTP-PEST)and SHP-2 have been documented to coordinate the phosphorylation and dephosphorylation of CAS.

Keywords： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

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Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels as potential soft biomaterials

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 509-515 doi: 10.1007/s11705-017-1613-7

Abstract: One of the commonly used enzymes is phosphatase, but the study of the substrates of phosphatases mainlyphosphoserine to the -terminal of a well-established self-assembling peptide backbone, (naphthalene-2-The incorporation of phosphotyrosine, another substrate of phosphatase, into the resulting precursor,

Keywords： enzyme-instructed self-assembly     phosphoserine     phosphatase     supramolecular hydrogel    

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第三届环境、工业和能源工程国际会议(EI2E 2019)

Conference Date: 19 Sep 2019

Conference Place: 宁夏银川

Administered by: APISE

第四届设计、机械和材料工程国际会议(D2ME 2019)

Conference Date: 26 Sep 2019

Conference Place: 釜山，韩国

Administered by: HKSME

第四届设计、机械和材料工程国际会议(D2ME 2019)

Conference Date: 26 Sep 2019

Conference Place: 釜山，韩国

Administered by: HKSME

Title Author Date Type Operation

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Journal Article

Measurement of bone alkaline phosphatase and relative study with osteosarcoma

YANG Zhiping, LI Jianmin, LI Xin, HUO Yanqing, SUN Guangzhi

Journal Article

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels as potential soft biomaterials

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Journal Article

第三届环境、工业和能源工程国际会议(EI2E 2019)

19 Sep 2019

Conference Information

第四届设计、机械和材料工程国际会议(D2ME 2019)

26 Sep 2019

Conference Information

Xiao Yonghong: Co-evolution of Clinical Highly Resistant and Highly Toxic Pathogens (2023-2-22)

10 Mar 2023

Conference Videos

第四届设计、机械和材料工程国际会议(D2ME 2019)

26 Sep 2019

Conference Information

Between Physical Activity, Sedentary Behavior and Cardiovascular Disease risk in Patients with Type 2Diabetes: MlDiab Study (2023-2-21)

2 Mar 2023

Conference Videos

Shenshizhao: Large Span Structure (2018-6-2)

22 Apr 2021

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Jian Li：iScience and Interdisciplinary Research (2020-4-2)

18 Apr 2022

Conference Videos